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KMID : 0624620150480050266
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BMB Reports
2015 Volume.48 No. 5 p.266 ~ p.270
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Isocitrate dehydrogenase mutations: new opportunities for translational research
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Keum Young-Sam
Choi Bu-Young
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Abstract
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Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the production of a new stereospecific metabolite, (R)-2-hydroxyglutarate (R-2HG). A large number of follow-up studies have been performed to address the molecular mechanisms of IDH1/2 mutations underlying how these events contribute to malignant transformation. In the meanwhile, the development of selective mutant IDH1/2 chemical inhibitors is being actively pursued in the scientific community and pharmaceutical industry. The present review article briefly discusses the important findings that highlight the molecular mechanisms of IDH1/2 mutations in cancer and provides a current status for development of selective mutant IDH1/2 chemical inhibitors.
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KEYWORD
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Cancer Metabolism, Isocitrate dehydrogenases (IDHs), Isocitrate (ICT), α-ketoglutarate (α-KG), (R)-2-hydroxyglutarate (R-2HG)
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